Displaying items by tag: ISO
ISO Class 7 Cleanroom Standards | Particulate, ACH, Requirements
In accordance with the ISO 14644 standards, ISO Class 7 cleanrooms represent a highly controlled environment that is engineered to maintain specific cleanliness values. The enclosed system encompasses ceiling-mounted fan filter units (FFUs) that generate a continuous supply of HEPA or ULPA-filtered air. In this article, we'll cover top-level considerations and standards for ISO 7 cleanroom design and construction. Additionally, we'll explore general principles for ISO 7 standards including particulate levels, ACH requirements, and equipment-based considerations among several unique applications.
What is an ISO-7 Cleanroom Classification?
ISO-7 cleanroom classification is a common medium level of the cleanroom classes. The ISO cleanroom standards are set by the International Organization for Standardization (https://www.iso.org/standards.html). They are a private international organization with a membership of 167 national standards bodies. The ISO cleanroom classification system used in the United States is primarily for pharmaceutical cleanrooms, medical device cleanrooms, biotech cleanrooms, life-science cleanrooms, and USP797/800 compounding cleanrooms. Europe and the rest of world uses the ISO cleanroom classification system for all industries except semiconductor.
ISO 7 Cleanroom Gowning Requirements
Proper cleaning procedures and maintenance are crucial to preserving the cleanliness, contamination control, and efficiency of cleanroom processes. Each cleanroom receives a different cleanliness classification based on the industrial application that the cleanroom operates in, as well as other environmental considerations. Each cleanroom class has a slightly different protocol when it comes to gowning, protocol, and supplies. For ISO 7 (Formerly Class 10,000) cleanrooms, these gowning requirements need careful consideration.
ISO 8 Cleanroom Design | Standards for Particulate Control
ISO 8 cleanroom design requires the understanding of several methodologies and procedures that evaluate airborne contamination levels including ISO 14644-1 to ISO 14644-8, ISO 14698-1, and ISO 14698-2.
Pharmaceutical Cleanroom Design & ISO 14644-16
Cleanrooms and controlled contamination environments are increasingly being used across many industrial sectors, including the pharmaceutical industry. An important issue is the operating cost associated with cleanroom energy consumption and, consequently, the identification of applicable energy containment measures. This article reviews pharmaceutical cleanroom calculations for non-unidirectional airflow against energy consumption with known sources of contamination and type of air diffusion used. It proposes alternative cases to compare potential economic savings from applying energy-saving measures proposed by ISO 14644-16.1
ISO Clean Room Standards and Other Classifications: Design, Redesign & Compliance
ISO Clean Room Standards and classifications are one of the most complex – yet essential – parts of designing and building a clean room. There are many important questions that need to be asked when planning for, designing and setting up your clean room. In this blog we explain how hygiene automation equipment can reduce or eliminate the risk of cross-contamination and bioburden while meeting clean room design requirements.
FS209E and ISO Cleanroom Standards
Before global cleanroom classifications and standards were adopted by the International Standards Organization (ISO), the U.S. General Service Administration’s standards (known as FS209E) were applied virtually worldwide. However, as the need for international standards grew, the ISO established a technical committee and several working groups to delineate its own set of standards.
Aerospace & Defense Cleanroom
Aerospace & Defense cleanroom classifications regulate a cleanroom’s degree of cleanliness and are defined by the allowed amount of contamination by particle count and size, as well as the necessary air change rates depending on the cleanroom’s classification level. Aerospace and defense cleanrooms are typically regulated by the classification standards of two major organizations: The International Standards Organization (ISO) and the American Society for Testing and Materials (ASTM).
Cleanroom Classifications (ISO 5-8)
Cleanrooms are classified according to the cleanliness level of the air inside them. The cleanroom class is the level of cleanliness the room complies with, according to the quantity and size of particles per volume of air. The primary authority in the US and Canada is the ISO classification system ISO 14644-1. This standard includes the cleanroom classes ISO 1, ISO 2, ISO 3, ISO 4, ISO 5, ISO 6, ISO 7, ISO 8 and ISO 9, with ISO 1 being the “cleanest” and ISO 9 the “dirtiest” class (but still cleaner than a regular room). The most common classes are ISO 7 and ISO 8.
The old Federal Standard 209 (class 100,000; 10,000; 1,000; 100; 10; 1) was withdrawn in 2001 and officially replaced by ISO-14644-1 in 1999, but it is still widely used.
In addition, cleanrooms must also comply with industry-specific and regional standards. For example, EU GGMP (A-B-C-D) applies to pharmaceutical products and USP (795, 797 and 800) to compounding pharmacies.
What Makes a Cleanroom a Clean Room?
Imagine if the medication we ingest and the electronic components we use were produced in rooms populated with chemical vapors, dust, and airborne particulates. These impurities would settle on capsules and circuits and contaminate them. Instead, manufacturers create a controlled environment a cleanroom to limit exposure to contaminants.
While not always sterile, a cleanroom follows accepted standards for maximum particulates per cubic meter. Air is filtered in and recirculated through HEPA air filters. Equipment is designed to generate minimal air impurities. Employees wear gloves, face masks, and head covers. Often, donning jumpsuits or smocks is also necessary. The room is cleaned daily, sometimes every few hours, according to rigorous quality procedures.