Displaying items by tag: cleanroom

Sunday, 01 January 2023 06:05

Under Pressure in Critical Environments

Controlled environments act as secluded clean spaces for performing select applications in a manner that protects the internal samples or materials and/or the workers involved. Air pressure is a key component of a cleanroom. The internal pressure and, by design, the differential pressure, are closely regulated and maintained.  Basic chemistry tells us that high pressure air has greater mass than low pressure air, and given the opportunity, will flow into the less dense environment.

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Sunday, 01 January 2023 06:05

Differential pressure measurement in cleanrooms

Rooms for critical processes i.e. cleanrooms as well as mini environments demand precise environmental monitoring technology and methods in order to operate consistently within specifications. This is not just about meeting standards, but more importantly about the quality of your products e.g. pharmaceutical medicines, semiconductor chips, or manufacturing processes. Robust and highly accurate differential pressure instruments from Novasina address pressure measurement challenges and help with the smooth operation of your cleanroom facilities.

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Sunday, 01 January 2023 06:05

Cleanroom Pressure Differential Testing

In any cleanroom facility the flow of clean air must ensure that the critical areas are maintained within international standards, to achieve this clean air should be cascaded from the cleanest areas to the least clean areas. This in turn is achieved through the use of pressure differentials between one area and the next.The purpose of the pressure differential test is to verify that the design and installation of the clean room system is suuficient to maintain the specified pressure difference between the clean areas and their surroundings.

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Between rooms of different cleanroom classes, pressure differences between 5 and 20 Pa must be ensured from cleaner room to less clean room. The minimal positive pressure of the cleanroom ensures that no air flows back into the cleaner area from the unclean area when doors are opened. The lowest contamination-level cleanroom itself is also accessed via airlocks for personnel and materials, where strong air currents stir up the particles present and extract them via filter systems. According to DIN EN ISO 14644-3, the pressure difference of a cleanroom to the personnel and material airlocks, to any cleanrooms of other purity classes as well as to the surroundings, must be tested. A test of differential pressure at the filter should also be carried out.

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For preventing cross-contamination coming from adjacent areas, several guidelines refer to a positive room-pressure of about 5- 20 (10-15) Pascals (Pa) as an essential factor for airflow from higher cleanliness to a lower cleanliness graded area under static conditions. To manufacturers of pharmaceutical products and the authorities controlling them, this cascaded pressure regime and room pressurization is seen as an essential element in preventing contamination (migration of particles) from adjacent outside areas.

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High-performance doors and flexible industrial fabric walls have evolved in recent years and are a viable option for various food and pharmaceutical applications.

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Thursday, 01 December 2022 18:45

How to choose the right cleanroom door

In a cleanroom, airflow management is critical. That’s because the slightest leak or imperfection can create contamination issues, and even very small amounts of dust and particles can have a significant impact on production processes. Cleanrooms are engineered environments with controlled levels of dirt, moisture, and particles. They are typically used in situations where there is potential for contamination by substances that would not normally be found at such concentrations. These may include laboratory workbenches, pharmaceutical production areas and fabrication sites for microelectronics. A cleanroom door plays an important role in keeping the air inside a cleanroom as well as keeping contaminants out of a cleanroom. If you’re looking to build or upgrade your facility with a cleanroom, here’s everything you need to know about cleanroom doors:

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Imagine you have an employee who keeps others from being productive and calls in sick more than anyone else. This person repeatedly causes cross-contamination and ignores your requests to improve their behavior.

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Finding the right cleanroom door for GMP pharmaceuticals can be a challenging task. Cleanroom doors are vital for protecting the integrity of pharmaceutical and food items and contribute to overall operational efficiency.

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From the time of Swiss watchmakers, who used bell jars to prevent dust from falling on their timepieces, to the development of high-efficiency particulate air (HEPA) filters for atomic energy production, manufacturers have worked to limit airborne contamination in their production environments. Today, ISO standards still emphasize air filtration and air distribution requirements, but the science of cleanroom design has necessarily gone beyond air filtration to include all components of the room, including floors, walls and especially doors.

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